NFL Kicks Off 2026 Season With Historic Game in Australia

The NFL officially launches its 2026 season with a historic matchup as the San Francisco 49ers take on the Los Angeles Rams at the Melbourne Cricket Ground in Australia on Thursday, September 10, 2026.

Why it matters: This game marks the NFL's first-ever regular-season contest in Australia, highlighting the league's global expansion efforts. The 49ers and Rams are both coming off strong seasons, each finishing 12-5 in 2025.

• The game is part of the Thursday Night Football series and is expected to draw considerable international attention.
• This matchup serves as a key early test for both teams, setting the tone for their 2026 campaigns.

Driving the news: The game kicks off at 8:35 p.m. ET (6:35 p.m. CT) and will be streamed live on Netflix and NFL+. With the Rams being 4-point favorites, this matchup is anticipated to be competitive.

• Los Angeles is favored with betting odds showing a moneyline of -210 for the Rams and +170 for the 49ers.
• The over/under for total points is set at 48.5, indicating expectations for a high-scoring game.

State of play: Both teams are looking to start the season strong after solid 2025 performances. The Rams are debuting Myles Garrett, a key offseason acquisition, but are missing Aaron Donald, who is still ramping up from a two-year retirement.

• George Kittle, the 49ers' star tight end, is also returning from injury, adding intrigue to the matchup.
• Players have adjusted their schedules to cope with the time change, with the 49ers arriving a week early to acclimate.

The big picture: The NFL has been actively working to expand its reach internationally, and this game is a major step in that direction. The league aims to cultivate a broader fan base outside the United States.

• By hosting games in international markets, the NFL hopes to increase viewership and engagement among fans worldwide.
• This matchup could pave the way for more international games in the future, especially if it proves successful.

What they're saying: Analysts are divided on the game's outcome, with predictions favoring the Rams slightly.

• Bookies.com predicts a close game, projecting a score of Rams 26, 49ers 22.
• Sports Betting Dime estimates the Rams will win by a larger margin, forecasting a score of Rams 29.4, 49ers 21.7.

By the numbers: The 49ers and Rams both finished last season with impressive records, setting the stage for a fierce rivalry.

• Both teams ended the 2025 season with identical 12-5 records, making this matchup even more meaningful.
• The Rams are currently favored by 4 points, a reflection of their strong offseason moves and existing roster talent.

Between the lines: The matchup highlights the teams' current rosters and their strategies for the upcoming season.

• The Rams' defense, featuring Myles Garrett and a returning Aaron Donald, is expected to be a dominant force.
• The 49ers will need to find ways to overcome their struggles running the ball from last season to compete effectively.

What's next: Following this historic game, the NFL's Thursday Night Football coverage will continue on Amazon Prime Video starting September 17.

• The next matchup features the Buffalo Bills hosting the Detroit Lions, which will also be available for streaming.
• Fans can expect a full slate of games throughout the season, with the NFL continuing its push for international engagement.